In this work, a reactive jamming detection scheme is proposed to solve the problem that reactive jamming attack disrupts the legal communication of ZigBee network. Multipleclass sequence distributing scheme and error bits detecting algorithm are proposed, which could obtain a set of abnormal received signal strength indication (RSSI) of error bits that would be subsequently identified by sequence probability ratio test (SPRT). An evaluation of the proposed scheme is validated experimentally and the results show that the solution is able to detect reactive jamming at success rate above 95% with relatively fewer communication and energy overheads. The measurement of packet delivery ratio (PDR) or topology changes is not considered in the scheme, which achieves effective detection against reactive jamming and enhancing security performance of ZigBee networks.