In order to meet the requirement of accurate measurement of widerange microcurrent in the electrochemical analysis system, a novel widerange precision potentiostat with low power dissipation is designed in this paper. New detection method based on compensated potential control and twostage proportional resistance method is proposed to achieve accurate measurement of microcurrent in the widerange of 10-10~10-3 A. The hardware circuit design of novel widerange precision potentiostat with low power dissipation is proposed, the transmission characteristic of the circuit is deduced by equivalent model circuit, and the bioelectrochemical analysis process is simulated by using homemade threeelectrode needle sensor and high precision resistors. The simulation and experimental results show that the signal output of the novel widerange precision potentiostat with low power dissipation is stable, the relative error of microcurrent detection in the widerange of 10-10~10-3 A is less than 1%, and the novel portable potentiostat according to the proposed method has practical application in tissue engineering hydraulic bioreactor intelligent monitoring system.