For the problem that the balise uplink (BU) signal transmission was interfered in the complex electromagnetic environment of high-speed railway, a denoising method based on the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) combined with wavelet packet adaptive threshold was proposed. Firstly, the CEEMDAN algorithm was used to decompose the simulated BU signal into 12 modal components, and the components were determined to be correlated or irrelevant based on the correlation coefficients; Then, the relevant components were reconstructed into the denoised BU signal after wavelet packet denoising processing; Finally, signal noise ratio (SNR) and root mean square error (RMSE) were selected as evaluation metrics to compare this method with six widely used denoising methods. The SNR increased by 0. 486 1 ~ 6. 144 dB and the RMSE decreased by 0. 054 9 ~ 11. 091. To verify the practical application effect of this method, this joint denoising method was adopted to denoise the measured BU signal. The results of simulation and experimental verification showed that the BU signal denoised by the joint denoising method not only effectively removed the noise component, but also preserved the signal features well, proving that this method can be applied to solve the problem of actual BU signal interference.