The geological conditions of the slopes on both sides of the reservoir area of the hydropower station are complex and changeable, and the stable working state of the slopes is closely related to the safe operation of the hydropower station. In this paper, the MEMS attitude sensors (gyroscopes and accelerometers) are arranged on the slopes in accordance with the array mode at the left slope cover layer of the reservoir area of the Yalong River Guandi Hydropower Station, and a real-time slope stability data acquisition system is established to determine the navigation target parameters attitude, orientation, velocity and position using the initial alignment The initial values of attitude, bearing, velocity and position are used to calculate the target attitude matrix, and then the acceleration and angular velocity under the load system acquired by the MEMS attitude sensors are converted to the navigation system in real time through the attitude matrix, which is used to calculate the slope change attitude matrix and displacement in real time to carry out experimental research. The experimental results show that the application of MEMS attitude sensor to slope displacement monitoring can achieve real-time acquisition of slope surface displacement data, displacement data acquisition accuracy can reach millimeter level, to meet the actual needs of engineering use, the research results are very important for real-time monitoring and analysis of the stability of slope surface displacement.