Timeinterleaved analogtodigital convert (TIADC) is used to improve the sampling rate of ADC system effectively. However, the timing mismatch, gain mismatch and offset mismatch are unavoidable in the TIADC system, which degrades the signal to noise ratio (SNR) of the TIADC. In this paper, an adaptive estimation method based on VSSLSM algorithm is proposed, which can estimate the timing mismatch and offset mismatch simultaneously. According to the estimated values, the timing and offset mismatches are corrected. The simulation results show that the proposed algorithm requires less than 128 samples to estimate the timing and offset mismatches of each subADC. The effectiveness of the proposed algorithm is verified in an actual TIADC system. The SNR of TIADC system is improved by 20 dB. The simulation and experiment results show that the proposed algorithm improves the performance of TIADC system effectively.