| 李鸿图,崔立棋,韩奇志,赵国忠.葡萄糖酸钙的太赫兹光谱特性研究[J].电子测量与仪器学报,2026,40(2):34-43 |
| 葡萄糖酸钙的太赫兹光谱特性研究 |
| Terahertz spectroscopy characteristics of calcium gluconate |
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| DOI： |
| 中文关键词: 葡萄糖酸钙 太赫兹时域光谱 浓度检测 吸收系数 折射率 |
| 英文关键词:calcium gluconate terahertz time-domain spectroscopy concentration detection absorption coefficient refractive index |
| 基金项目:国家重点研发计划（2021YFB3200102）、国家自然科学基金（62071312）项目资助 |
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| Author | Institution |
| Li Hongtu | 1.Key Laboratory of Terahertz Optoelectronics of the Ministry of Education, Beijing 100048, China;
2.Department of Physics, Capital Normal University, Beijing 100048, China |
| Cui Liqi | 1.Key Laboratory of Terahertz Optoelectronics of the Ministry of Education, Beijing 100048, China;
2.Department of Physics, Capital Normal University, Beijing 100048, China |
| Han Qizhi | 1.Key Laboratory of Terahertz Optoelectronics of the Ministry of Education, Beijing 100048, China;
2.Department of Physics, Capital Normal University, Beijing 100048, China |
| Zhao Guozhong | 1.Key Laboratory of Terahertz Optoelectronics of the Ministry of Education, Beijing 100048, China;
2.Department of Physics, Capital Normal University, Beijing 100048, China |
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| 中文摘要: |
| 针对葡萄糖酸钙在临床检测中的关键作用，设计了一种基于太赫兹时域光谱（THz-TDS）的检测方法，该方法能够实现快速、无损且高精度的光谱分析。首先，采用压片法制备了质量百分比为2.5%~20%的葡萄糖酸钙片状样品，并配置了以水-甘油混合物为溶剂的5~20 mmol/L摩尔浓度溶液。利用自主搭建的THz-TDS透射系统，在室温和真空环境下对这些样品进行光谱检测。随后，通过傅里叶变换将时域信号转为频域谱，提取得到的吸收系数与折射率谱，并通过线性拟合建立浓度与光谱参数之间的定量关系。实验结果表明，片状样品在1.19、1.39、1.66、1.87和2.29 THz处展示出显著的特征吸收峰。数据分析显示，这些吸收峰的吸收系数与样品质量百分比呈明显的线性关系，其中1.66 THz处的线性拟合度高达0.991。而对于溶液样品，由于溶剂的强吸收特性，折射率谱分析显示在1.66 THz处，折射率与摩尔浓度之间也具有良好的线性关系，拟合度为0.987。结果表明，该方法不仅能够有效定量分析样品的吸收特性，还可以准确评估样品的色散（折射率）特性。结合微型THz-TDS设备和人工智能算法后，此技术在临床血钙监测和药物真伪鉴别等应用中展现出显著的科学研究价值和应用潜力。 |
| 英文摘要: |
| Given the critical role of calcium gluconate in clinical detection, we have designed a detection method based on terahertz time-domain spectroscopy (THz-TDS), which enables rapid, non-destructive, and high-precision spectral analysis. Initially, calcium gluconate film samples were prepared using a compression method with a mass percentage ranging from 2.5% to 20%. Additionally, solutions with molar concentrations of 5 to 20 mmol/L were prepared using a water-glycerol mixture as the solvent. These samples were analyzed using a self-constructed THz-TDS transmission system under room temperature and vacuum conditions. Subsequently, Fourier transform was applied to convert the time-domain signals into frequency-domain spectra, from which the absorption coefficient and refractive index spectra were extracted. A quantitative relationship between concentration and spectral parameters was established through linear fitting. The experimental results indicate that the film samples exhibit distinct absorption peaks at 1.19, 1.39, 1.66, 1.87, and 2.29 THz. Data analysis reveals that the absorption coefficients at these peaks demonstrate a clear linear relationship with the sample’s mass percentage, particularly at 1.66 THz, where the linear fitting degree reaches 0.991. For solution samples, due to the strong absorption characteristics of the solvent, the refractive index spectrum analysis shows a good linear relationship between the refractive index and molar concentration at 1.66 THz, with a fitting degree of 0.987. These results suggest that this method not only allows for effective quantitative analysis of the absorption properties of samples but also provides accurate evaluation of the dispersion (refractive index) properties. When combined with miniaturized THz-TDS equipment and artificial intelligence algorithms, this technology demonstrates significant scientific research value and application potential in clinical blood calcium monitoring and drug authenticity identification. |
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